Systemic IL-6 regulation of eccentric contraction-induced muscle protein synthesis
نویسندگان
چکیده
منابع مشابه
Inflammatory signalling regulates eccentric contraction‐induced protein synthesis in cachectic skeletal muscle
BACKGROUND Skeletal muscle responds to eccentric contractions (ECC) with an anabolic response that involves the induction of protein synthesis through the mechanistic target of rapamycin complex 1. While we have reported that repeated ECC bouts after cachexia initiation attenuated muscle mass loss and inflammatory signalling, cachectic muscle's capacity to induce protein synthesis in response t...
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Skeletal muscle cytoskeletal proteins are receiving more attention recently based on their importance in maintaining muscle integrity, their role in transmitting force throughout the cell, and their involvement in muscle diseases. In this report, the authors focus on the intermediate filament system of skeletal muscle composed of the protein desmin. Desmin is shown to transmit force from myofib...
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1 Faculty of Medicine and Surgery, University of “Tor Vergata” Rome (Italy). 2 SPO Sport Performance Optimization Lab, CNMSS, Tunis (Tunisia) 3 UR CIAMS – Motor Control and Perception Group, Sport Sciences Department, Université Paris-Sud, Orsay (France). 4 School of Exercise and Sport Science, University of Verona (Italy). 5 Orthopaedic and Sports Medicine Hospital, Doha (Qatar). Authors subm...
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Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase satellite cell proliferation, or cause muscle wa...
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Muscle contraction and force regulation in skeletal muscle have been thought to occur exclusively through the relative sliding of and the interaction between the contractile filaments actin and myosin. While this two-filament sarcomere model has worked well in explaining the properties of isometrically and concentrically contracting muscle, it has failed miserably in explaining experimental obs...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2018
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00063.2018